Soluble Polymer-Supported Synthesis of Tertiary Amines
Date
2012-11-20
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Abstract
The synthesis of tertiary amines on a modified soluble polymer,
poly(ethylene glycol) (PEG), is described. The PEG-bound quaternary
intermediates were assembled via Michael addition reaction,
followed by alkylation. Cleavage from the soluble polymer support
was induced by insoluble weak basic resin, to afford the target
tertiary amines in excellent purity.
Description
The synthesis of tertiary amines on a modified soluble polymer,
poly(ethylene glycol) (PEG), is described. The PEG-bound quaternary
intermediates were assembled via Michael addition reaction,
followed by alkylation. Cleavage from the soluble polymer support
was induced by insoluble weak basic resin, to afford the target
tertiary amines in excellent purity.
Keywords
Tertiary amine; Soluble polymer; Support; Synthesis.