Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)
Date
2012-11-20
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Abstract
Discovery of the First Potent and
Selective Small Molecule Opioid
Receptor-like (ORL1) Antagonist:
1-[(3R,4R)-1-Cyclooctylmethyl-3-
hydroxymethyl-4-piperidyl]-3-ethyl-
1,3-dihydro-2H-benzimidazol-2-one
(J-113397)
Description
Discovery of the First Potent and
Selective Small Molecule Opioid
Receptor-like (ORL1) Antagonist:
1-[(3R,4R)-1-Cyclooctylmethyl-3-
hydroxymethyl-4-piperidyl]-3-ethyl-
1,3-dihydro-2H-benzimidazol-2-one
(J-113397)
Keywords
Discovery of the First Potent and Selective Small Molecule Opioid Receptor-like (ORL1) Antagonist: 1-[(3R,4R)-1-Cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl- 1,3-dihydro-2H-benzimidazol-2-one (J-113397)