TOXIC AMINES AND ALKALOIDS FROM ACACIA RIGIDULA
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Date
2012-11-14
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Abstract
Acacia ri`idula Benth[\ blackbrush\ is a shrub found growing on rocky ridges in west and southwest
Texas and northern Mexico[ Consumption of blackbrush and a related species guajillo\ Acacia berlandieri
Benth[\ has been associated with a locomotor ataxia known as {{limber leg||[ In an e}ort to identify the
mechanism of this toxicity\ blackbrush was subjected to rigorous chemical analysis[ In addition to the four
previously detected amines\N!methyl!b!phenethylamine\ tyramine\N!methyltyramine\ and hordenine\ 39 other
alkaloids and amines were isolated and identi_ed by GC!MS[ These alkaloids and amines included nicotine\
N\N!dimethyltryptamine\ mescaline\ several tetrahydroisoquinoline alkaloids\ and four amphetamines[ A sig!
ni_cant increase in the number and relative quantities of these compounds was observed in late season foliage[
0887 Elsevier Science Ltd[ All rights reserved
Description
Acacia ri`idula Benth[\ blackbrush\ is a shrub found growing on rocky ridges in west and southwest
Texas and northern Mexico[ Consumption of blackbrush and a related species guajillo\ Acacia berlandieri
Benth[\ has been associated with a locomotor ataxia known as {{limber leg||[ In an e}ort to identify the
mechanism of this toxicity\ blackbrush was subjected to rigorous chemical analysis[ In addition to the four
previously detected amines\N!methyl!b!phenethylamine\ tyramine\N!methyltyramine\ and hordenine\ 39 other
alkaloids and amines were isolated and identi_ed by GC!MS[ These alkaloids and amines included nicotine\
N\N!dimethyltryptamine\ mescaline\ several tetrahydroisoquinoline alkaloids\ and four amphetamines[ A sig!
ni_cant increase in the number and relative quantities of these compounds was observed in late season foliage[
0887 Elsevier Science Ltd[ All rights reserved
Keywords
Acacia ri`udula^ blackbrush^ Leguminosae^ alkaloids^ GC:MS[