THE SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 2,3 “SECO” FENTANYL
Date
2012-11-21
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Abstract
A structurally novel, 2,3 “seco” analogue of fentanyl has been synthesized by a
short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower
than fentanyl but still several times higher than morphine
Description
A structurally novel, 2,3 “seco” analogue of fentanyl has been synthesized by a
short and efficient procedure. Central-analgesic activity was found to be ca. 30 times lower
than fentanyl but still several times higher than morphine
Keywords
Fentanyl, open-chained analogues, central analgesics