Jared M. WagnerCharles J. McElhinnyJr.Anita H. Lewin, Anita H. LewinF. Ivy Carroll2012-11-062025-02-172012-11-062012-11-06https://dl.ftveti.edu.et/handle/123456789/3895Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.en© 2003 Elsevier Ltd. All rights reserved.Article