DIRECT SYNTHESIS OF g-BUTYROLACTONES VIA g-PHENYL SUBSTITUTED BUTYRIC ACIDS MEDIATED BENZYL RADICAL CYCLIZATION

N. O. MahmoodiM. Jazayri2012-11-202025-02-172012-11-202012-11-19https://dl.ftveti.edu.et/handle/123456789/4154Synthesis of several g-butyrolactones with aromatic substitution at carbon 5 from comparative g-aryl acids with 25–85% yield are covered. The straight oxidation in the presence of peroxydisulphate-copper(II)chloride system in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to g-butyrolactone, through stable benzylic radical intermediateSynthesis of several g-butyrolactones with aromatic substitution at carbon 5 from comparative g-aryl acids with 25–85% yield are covered. The straight oxidation in the presence of peroxydisulphate-copper(II)chloride system in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to g-butyrolactone, through stable benzylic radical intermediateenDIRECT SYNTHESIS OF g-BUTYROLACTONES VIA g-PHENYL SUBSTITUTED BUTYRIC ACIDS MEDIATED BENZYL RADICAL CYCLIZATIONDIRECT SYNTHESIS OF g-BUTYROLACTONES VIA g-PHENYL SUBSTITUTED BUTYRIC ACIDS MEDIATED BENZYL RADICAL CYCLIZATIONArticle