DA´ VID KOZMAELEME´ R FOGASSY2012-11-202025-02-172012-11-202012-11-20https://dl.ftveti.edu.et/handle/123456789/4222Solvent-free optical resolution of N-methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O8-dibenzoyltartaric acid, O,O8-di-p-toluoyltartaric acid, 6-methoxy-a-methyl-2-naphthaleneacetic acid (Naproxen), the cis-permetrinic acid, and the 2-phenoxypropionic acid. Among them the O,O8-dibenzoyltartaric acid in water-free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial-scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley-Liss, IncSolvent-free optical resolution of N-methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O8-dibenzoyltartaric acid, O,O8-di-p-toluoyltartaric acid, 6-methoxy-a-methyl-2-naphthaleneacetic acid (Naproxen), the cis-permetrinic acid, and the 2-phenoxypropionic acid. Among them the O,O8-dibenzoyltartaric acid in water-free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial-scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley-Liss, Incenoptical resolution; diastereoisomeric salts; solvent-free process; distillation; O,O8-dibenzoyltartaric acid; O,O8-di-p-toluoyltartaric acid; 6-methoxy- a-methyl-2-naphthaleneacetic acid; cis-permetrinic acid; 2-phenoxypropionic acidArticle