Uncatalyzed conversion of linear a-nitro ketones into amides by reaction with primary amines under solventless conditions
Date
2012-11-20
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Abstract
The reaction of linear a-nitro ketones with primary amines allows the formation of amides through the cleavage of the carbon–
carbon bond between the carbonyl group and the carbon-nitro group moiety, promoted by the nucleophilic effect of the amine. The reaction is
performed at room temperature, without any catalyst and/or solvent. q 2003 Elsevier Science Ltd. All rights reserved
Description
The reaction of linear a-nitro ketones with primary amines allows the formation of amides through the cleavage of the carbon–
carbon bond between the carbonyl group and the carbon-nitro group moiety, promoted by the nucleophilic effect of the amine. The reaction is
performed at room temperature, without any catalyst and/or solvent. q 2003 Elsevier Science Ltd. All rights reserved
Keywords
Uncatalyzed conversion of linear a-nitro ketones into amides by reaction with primary amines under solventless conditions