Synthesis of various 2H-benzopyran compounds and their kinetic resolution by asymmetric hydrolysis of their racemic acetates mediated by lipases
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2012-11-09
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Abstract
The preparation of 2H-benzopyrans from bromophenols and tertiary allylic alcohols is described. The
reaction is characterised by its mildness, good yields and ease of work-up. Kinetic resolution of the latter
up to 95% ee was obtained by using enzyme-catalysed enantioselective hydrolysis. # 2000 Elsevier Science
Ltd. All rights reserved.
Description
The preparation of 2H-benzopyrans from bromophenols and tertiary allylic alcohols is described. The
reaction is characterised by its mildness, good yields and ease of work-up. Kinetic resolution of the latter
up to 95% ee was obtained by using enzyme-catalysed enantioselective hydrolysis. # 2000 Elsevier Science
Ltd. All rights reserved.
Keywords
Synthesis of various 2H-benzopyran compounds and their kinetic resolution by asymmetric hydrolysis of their racemic acetates mediated by lipases