Convenient Method for the Synthesis of Chiral cx,a-Diphenyl-2-pyrrolidinemethanol

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2012-11-20

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Abstract

A simplified, convenient synthesis of chiral a,a-diphewl- Z-pyrrolidinemethanol involving one step Nand G-protection of S-proline using ethylchloroforeate followed by Grignard addition-alkaline hydrolysis WCEl/CXl$Xli)s described

Description

A simplified, convenient synthesis of chiral a,a-diphewl- Z-pyrrolidinemethanol involving one step Nand G-protection of S-proline using ethylchloroforeate followed by Grignard addition-alkaline hydrolysis WCEl/CXl$Xli)s described

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Convenient Method for the Synthesis of Chiral cx,a-Diphenyl-2-pyrrolidinemethanol

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