A Single Step Reductive Amination of Carbonyl Compounds with Polymethylhydrosiloxane-Ti(OiPr)4 #
Date
2012-11-21
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Abstract
Highly chemoselective ‘one pot’ amination of carbonyl
groups is achieved using polymethylhydrosiloxane (PMHS) as reductant
and Ti(OiPr)4 as activator. A comparative study with other
activators such as AlCl3 and Pd-C was also studied
Description
Highly chemoselective ‘one pot’ amination of carbonyl
groups is achieved using polymethylhydrosiloxane (PMHS) as reductant
and Ti(OiPr)4 as activator. A comparative study with other
activators such as AlCl3 and Pd-C was also studied
Keywords
carbonyl compounds, amines, PMHS, reductive amination, titanium(IV)isopropoxide