Stereospecific synthesis of amphetamines

dc.contributor.author	Jared M. Wagner
dc.contributor.author	Charles J. McElhinny
dc.contributor.author	Jr.Anita H. Lewin, Anita H. Lewin
dc.contributor.author	F. Ivy Carroll
dc.date.accessioned	2012-11-06T10:21:10Z
dc.date.accessioned	2025-02-17T13:59:21Z
dc.date.available	2012-11-06T10:21:10Z
dc.date.issued	2012-11-06
dc.description	Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.	en_US
dc.description.abstract	Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.	en_US
dc.identifier.uri	https://dl.ftveti.edu.et/handle/123456789/3895
dc.language.iso	en	en_US
dc.subject	© 2003 Elsevier Ltd. All rights reserved.	en_US
dc.title	Stereospecific synthesis of amphetamines	en_US
dc.type	Article	en_US

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