DIRECT SYNTHESIS OF g-BUTYROLACTONES VIA g-PHENYL SUBSTITUTED BUTYRIC ACIDS MEDIATED BENZYL RADICAL CYCLIZATION

Abstract

Synthesis of several g-butyrolactones with aromatic substitution at carbon 5 from comparative g-aryl acids with 25–85% yield are covered. The straight oxidation in the presence of peroxydisulphate-copper(II)chloride system in aqueous medium was applied. The reaction is highly regioselective and leads exclusively to g-butyrolactone, through stable benzylic radical intermediate