Solvent-Free Optical Resolution of N-methylamphetamine by Distillation After Partial Diastereoisomeric Salt Formation
| dc.contributor.author | DA´ VID KOZMA | |
| dc.contributor.author | ELEME´ R FOGASSY | |
| dc.date.accessioned | 2012-11-20T13:09:04Z | |
| dc.date.accessioned | 2025-02-17T14:02:07Z | |
| dc.date.available | 2012-11-20T13:09:04Z | |
| dc.date.issued | 2012-11-20 | |
| dc.description | Solvent-free optical resolution of N-methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O8-dibenzoyltartaric acid, O,O8-di-p-toluoyltartaric acid, 6-methoxy-a-methyl-2-naphthaleneacetic acid (Naproxen), the cis-permetrinic acid, and the 2-phenoxypropionic acid. Among them the O,O8-dibenzoyltartaric acid in water-free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial-scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley-Liss, Inc | en_US |
| dc.description.abstract | Solvent-free optical resolution of N-methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O8-dibenzoyltartaric acid, O,O8-di-p-toluoyltartaric acid, 6-methoxy-a-methyl-2-naphthaleneacetic acid (Naproxen), the cis-permetrinic acid, and the 2-phenoxypropionic acid. Among them the O,O8-dibenzoyltartaric acid in water-free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial-scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley-Liss, Inc | en_US |
| dc.identifier.uri | https://dl.ftveti.edu.et/handle/123456789/4222 | |
| dc.language.iso | en | en_US |
| dc.subject | optical resolution; diastereoisomeric salts; solvent-free process; distillation; O,O8-dibenzoyltartaric acid; O,O8-di-p-toluoyltartaric acid; 6-methoxy- a-methyl-2-naphthaleneacetic acid; cis-permetrinic acid; 2-phenoxypropionic acid | en_US |
| dc.title | Solvent-Free Optical Resolution of N-methylamphetamine by Distillation After Partial Diastereoisomeric Salt Formation | en_US |
| dc.type | Article | en_US |
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