Solid-Supported Reagents in Organic Synthesis
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Date
2012-11-09
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Abstract
The current interest in solid-phase organic synthesis has led to a renewed interest in a
complementary technique in which solid supported reagents are used in solution phase chemistry.
This technique obviates the need for attachment of the substrate to a solid-support, and enables
the chemist to monitor the reactions using familiar analytical techniques. The purpose of this review
is to increase awareness of the wide range of useful transformations which can be accomplished
using solid-supported reagents. © 1999 John Wiley & Sons, Inc. Med Res Rev 19, 97–148, 1999
Description
The current interest in solid-phase organic synthesis has led to a renewed interest in a
complementary technique in which solid supported reagents are used in solution phase chemistry.
This technique obviates the need for attachment of the substrate to a solid-support, and enables
the chemist to monitor the reactions using familiar analytical techniques. The purpose of this review
is to increase awareness of the wide range of useful transformations which can be accomplished
using solid-supported reagents. © 1999 John Wiley & Sons, Inc. Med Res Rev 19, 97–148, 1999
Keywords
solid-supported reagents; solid-phase reagents; polymer-supported reagents; parallel synthesis; scavenger reagents; ion-exchange resins; solution-phase synthesis; combinatorial chemistry