Browsing by Author "Malayalam Sridhar"

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    An a-aminomethyl carbanion equivalent via a novel Barbier reaction: (1H-naphtho[1,8-de]-1,2,3-triazin-2-yl)methyl anion
    (2012-11-20) Sosale Chandrasekhar; Malayalam Sridhar
    A novel sonication-promoted Barbier reaction putatively generated the titled species from the corre- sponding naphthotriazinylmethyl chloride and magnesium in THF: its formal addition to a variety of carbonyl compounds in situ occurred in excellent yields. Subsequent catalytic hydrogenolysis of the triazine moiety demasked the amine, thus de®ning a route to various phenylethylamines (including the alkaloid `mescaline'), or ethanolamines (in two cases), in excellent overall yields. # 2000 Elsevier Science Ltd. All rights reserved.