Browsing by Author "Jr.Anita H. Lewin, Anita H. Lewin"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Stereospecific synthesis of amphetamines
    (2012-11-06) Jared M. Wagner; Charles J. McElhinny; Jr.Anita H. Lewin, Anita H. Lewin; F. Ivy Carroll
    Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.