Browsing by Author "ELEME´ R FOGASSY"

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    Solvent-Free Optical Resolution of N-methylamphetamine by Distillation After Partial Diastereoisomeric Salt Formation
    (2012-11-20) DA´ VID KOZMA; ELEME´ R FOGASSY
    Solvent-free optical resolution of N-methylamphetamine was developed by distillation after partial diastereoisomeric salt formation. From the 18 chiral acids tested by this method, five provide by this method resolution: O,O8-dibenzoyltartaric acid, O,O8-di-p-toluoyltartaric acid, 6-methoxy-a-methyl-2-naphthaleneacetic acid (Naproxen), the cis-permetrinic acid, and the 2-phenoxypropionic acid. Among them the O,O8-dibenzoyltartaric acid in water-free form provided the more effective resolution. The efficiency of this resolution S = 0.74 is in the range of the industrial-scale resolutions and not worse than the efficiency achieved by optical resolution via fractional crystallization. Chirality 13:428–430, 2001. © 2001 Wiley-Liss, Inc