Browsing by Author "Charles J. McElhinny"

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    Stereospecific synthesis of amphetamines
    (2012-11-06) Jared M. Wagner; Charles J. McElhinny; Jr.Anita H. Lewin, Anita H. Lewin; F. Ivy Carroll
    Abstract—Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine.
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    Stereospecific synthesis of amphetamines
    (2012-11-14) Jared M. Wagner; Charles J. McElhinny; Jr.Anita H. Lewin; F. Ivy Carroll
    Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine. © 2003 Elsevier Ltd. All rights reserved
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    Stereospecific synthesis of amphetamines
    (2012-11-20) Jared M. Wagner; Charles J. McElhinny; Jr.Anita H. Lewin; F. Ivy Carroll
    Regioselective addition of aryl lithium to commercially available (S)-(+)-propylene oxide provides the corresponding (S)-aryl-2-propanol. The (R)-amphetamine is obtained by conversion of the alcohol to the tosylate followed by azide displacement and hydrogenation. Mitsunobu conversion of the alcohol to the (R)-bromide followed by azide displacement and hydrogenation affords the (S)-amphetamine. © 2003 Elsevier Ltd. All rights reserved