Browsing by Author "B. Meek"
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Item Novel Analgesics and Molecular Rearrangements in the Morphine-Thebaine Group. 11.' Alcohols Derived from 6,14-endo-Etheno- and 6,14-endo-Ethanotetrahydrothebaine(2012-11-20) K. W. Bentley; G. Hardy; B. MeekA series of secondary and tertiary alcohols have been prepared by the reduction and reaction with Grignard reagents of the aldehyde I (R = H), the ketones I (R = Me, Et, n-Pr, and Ph), and their 6,14-ethano analogs. The stereospecificity of the reactions is explained. In this way analgesics of very high potency, up to 500 times that of morphine, have been obtainedItem Novel Analgesics and Molecular Rearrangements in the Morphine-Thebaine Group. 11.' Alcohols Derived from 6,14-endo-Etheno- and 6,14-endo-Ethanotetrahydrothebaine(2012-11-14) K. W. Bentley; D. G. Hardy; B. MeekA series of secondary and tertiary alcohols have been prepared by the reduction and reaction with Grignard reagents of the aldehyde I (R = H), the ketones I (R = Me, Et, n-Pr, and Ph), and their 6,14-ethano analogs. The stereospecificity of the reactions is explained. In this way analgesics of very high potency, up to 500 times that of morphine, have been obtained